THRA Antikörper (Isoform 1, N-Term)

Produktnummer ABIN401406

Produktdetails anti-THRA Antikörper

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Bindungsspezifität: Isoform 1, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts with Human THRA protein. A BLAST analysis was used to suggest cross-reactivity with THRA from Mouse, Human and Rat based on a 100 % homology with the immunizing sequence. Cross-reactivity with THRA from other sources has not been determined.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide corresponding to a region near the amino terminus of Human THRA isoform 1 protein . Genename: THRA

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/650,000. Western Blot: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.89 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.12 M Sodium Chloride, pH 7.2, 0.01 % (w/v) Sodium Azide, None

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu THRA

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Andere Bezeichnung: THRA / ERBA1 (THRA Produkte)

Synonyme: AR7 antikoerper, CHNG6 antikoerper, EAR7 antikoerper, ERB-T-1 antikoerper, ERBA antikoerper, ERBA1 antikoerper, NR1A1 antikoerper, THRA1 antikoerper, THRA2 antikoerper, c-ERBA-1 antikoerper, C-ERBA-ALPHA antikoerper, TRalpha antikoerper, c-erba antikoerper, erba antikoerper, nr1a1-A antikoerper, thra-A antikoerper, thra1 antikoerper, TR[a]1 antikoerper, nr1a1 antikoerper, thra antikoerper, thral antikoerper, tra antikoerper, tra1 antikoerper, wu:fb59g07 antikoerper, Thra1 antikoerper, 6430529J03Rik antikoerper, AW259572 antikoerper, Erba antikoerper, Nr1a1 antikoerper, Rvr antikoerper, T3R[a] antikoerper, T3Ralpha antikoerper, Thra2 antikoerper, C-ERBA ALPHA1 antikoerper, Thra antikoerper, fTHRalphaA antikoerper, nr1a1-a antikoerper, thyroid hormone receptor, alpha antikoerper, thyroid hormone receptor, alpha L homeolog antikoerper, thyroid hormone receptor alpha a antikoerper, thyroid hormone receptor alpha antikoerper, thyroid hormone receptor alpha-A antikoerper, THRA antikoerper, thra.L antikoerper, thraa antikoerper, Thra antikoerper, tr-alpha antikoerper, LOC109641414 antikoerper

Hintergrund: Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodothyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. This antibody recognizes THRA isoform 1. Isoform 1 has a distinct C-terminus compared to isoform 2.Synonyms: C-erbA-alpha, EAR-7, EAR7, NR1A1, Nuclear receptor subfamily 1 group A member 1, THRA1, THRA2, Thyroid hormone receptor alpha, c-erbA-1

Gen-ID: 7067

NCBI Accession: NP_001177847

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development