CRTC1 Antikörper (AA 19-34)

Produktnummer ABIN401346

Produktdetails anti-CRTC1 Antikörper

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Bindungsspezifität: AA 19-34

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRTC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody is directed against MECT1 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Zebrafish, Pufferfish, Bovine.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Immunogen: Synthetic peptide corresponding to amino acids 19-34 of human MECT1 protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10,000 - 1/40,000. Western Blot: 1/500 - 1/2,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.95 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Details zu CRTC1

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Andere Bezeichnung: CRTC1 / MECT1 (CRTC1 Produkte)

Synonyme: MECT1 antikoerper, TORC-1 antikoerper, TORC1 antikoerper, WAMTP1 antikoerper, AI413414 antikoerper, Mect1 antikoerper, R74955 antikoerper, mKIAA0616 antikoerper, CRTC1 antikoerper, crtc1 antikoerper, fc68c05 antikoerper, pde4cb antikoerper, si:ch211-255d18.1 antikoerper, si:ch211-255d18.8 antikoerper, wu:fc68c05 antikoerper, CREB regulated transcription coactivator 1 antikoerper, CREB regulated transcription coactivator 1b antikoerper, CRTC1 antikoerper, Crtc1 antikoerper, crtc1 antikoerper, crtc1b antikoerper

Hintergrund: MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1, Transducer of regulated cAMP response elementbinding protein 1, TORC1, and Transducer of CREB protein 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.Synonyms: CREB-regulated transcription coactivator 1, KIAA0616, Mucoepidermoid carcinoma translocated protein 1, TORC1, Transducer of regulated cAMP response element-binding protein 1, WAMTP1

Gen-ID: 23373

NCBI Accession: NP_001091952

UniProt: Q6UUV9