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RFFL Antikörper (N-Term)

RFFL Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN401034
  • Target Alle RFFL Antikörper anzeigen
    RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))
    Bindungsspezifität
    • 15
    • 14
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-363, N-Term
    Reaktivität
    • 42
    • 22
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    Human, Maus, Ratte, Rind (Kuh), Hund
    Wirt
    • 39
    • 3
    Kaninchen
    Klonalität
    • 40
    • 2
    Polyklonal
    Konjugat
    • 18
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RFFL Antikörper ist unkonjugiert
    Applikation
    • 40
    • 22
    • 13
    • 13
    • 3
    • 3
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody is directed against RFFL protein.
    Kreuzreaktivität (Details)
    Species reactivity (expected):Canine, Rat, Mouse, Bovine.
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity chromatography on Protein A
    Immunogen
    Recombinant protein corresponding to amino acids 1-363 of human RFFL protein
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA: 1/4000 - 1/20000. Western Blot: 1/500 - 1/3000. Immunohistochemistry: 1/500 - 1/3000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore with 0.1 mL of deionized water or equivalent.
    Konzentration
    5.0 mg/mL (by UV absorbance at 280 nm)
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))
    Andere Bezeichnung
    RFFL / RNF189 (RFFL Produkte)
    Synonyme
    MGC84042 antikoerper, RFFL antikoerper, Rffl antikoerper, 1700051E09Rik antikoerper, 4930516L10Rik antikoerper, BG080975 antikoerper, Carp2 antikoerper, CARP-2 antikoerper, CARP2 antikoerper, FRING antikoerper, RIFIFYLIN antikoerper, RNF189 antikoerper, RNF34L antikoerper, ring finger and FYVE like domain containing E3 ubiquitin protein ligase antikoerper, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase L homeolog antikoerper, ring finger and FYVE-like domain containing 1 antikoerper, ring finger and FYVE like domain containing protein antikoerper, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase antikoerper, RFFL antikoerper, rffl.L antikoerper, Rffl antikoerper
    Hintergrund
    RFFL, also known as Rififylin, RING finger and FYVE-like domaincontaining protein 1, FYVE-RING finger protein, Sakura, Fring, Caspases-8 and -10-associated RING finger protein 2, CARP-2, Caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like, is a novel modulator of NF-kappaB activation. RFFL possesses E3 ubiquitin protein ligase activity and has been shown to regulate the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. RFFL also possesses anti-apoptotic activity and may bind phosphatidylinositol phosphates. RFFL is a membrane bound cytoplasmic protein that is expressed ubiquitously. RFFL can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes and is rapidly degraded after stimulation with TNFSF10, and probably by caspases. Multiple transcript variants have been detected for this protein.Synonyms: CARP-2, CARP2, Caspases-8 and -10-associated RING finger protein 2, E3 ubiquitin-protein ligase rififylin, FYVE-RING finger protein Sakura, Fring, RIFIFYLIN, RING finger protein 189, RING finger protein 34-like, RNF34L
    Gen-ID
    117584
    NCBI Accession
    NP_001017368
    UniProt
    Q8WZ73
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