SGOL2 Antikörper (AA 391-419)

Produktnummer ABIN5538697

Produktdetails anti-SGOL2 Antikörper

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Bindungsspezifität: AA 391-419

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SGOL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SGOL2

Target: SGOL2 (Shugoshin-Like 2 (SGOL2))

Andere Bezeichnung: SGOL2 (SGOL2 Produkte)

Synonyme: SGO2 antikoerper, TRIPIN antikoerper, 1110007N04Rik antikoerper, 4932411A20Rik antikoerper, 5730576N04Rik antikoerper, AU018846 antikoerper, AV008062 antikoerper, D1Ertd8e antikoerper, Tripin antikoerper, shugoshin 2 antikoerper, shugoshin 2A antikoerper, SGO2 antikoerper, Sgo2a antikoerper

Hintergrund: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Molekulargewicht: 145 kDa

Gen-ID: 151246

UniProt: Q562F6