This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This CLP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the C-terminal region of human CLP1.
CLP1
Reaktivität: Human
WB, IF (cc), IF (p)
Wirt: Kaninchen
Polyclonal
Alexa Fluor 594
Applikationshinweise
For WB starting dilution is: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.5 mg/mL
Buffer
Supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Target
CLP1
(Cleavage and Polyadenylation Factor I Subunit 1 (CLP1))
Heab antikoerper, RGD1307679 antikoerper, AI462438 antikoerper, ACDP1 antikoerper, CLP-1 antikoerper, CGP-39 antikoerper, GP-39 antikoerper, SPC-40 antikoerper, SPS-40 antikoerper, YKL-40 antikoerper, HEAB antikoerper, hClp1 antikoerper, fa28a12 antikoerper, wu:fa28a12 antikoerper, clp1 antikoerper, cleavage and polyadenylation factor I subunit 1 antikoerper, CLP1, cleavage and polyadenylation factor I subunit antikoerper, cyclin and CBS domain divalent metal cation transport mediator 1 antikoerper, chitinase 3-like 1 (cartilage glycoprotein-39) antikoerper, cleavage and polyadenylation factor I subunit 1 L homeolog antikoerper, Clp1 antikoerper, CNNM1 antikoerper, CHI3L1 antikoerper, CLP1 antikoerper, clp1 antikoerper, clp1.L antikoerper
Hintergrund
Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing, this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.