NUMBL Antikörper (C-Term)

Produktnummer ABIN5537231

Produktdetails anti-NUMBL Antikörper

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Bindungsspezifität: AA 572-600, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NUMBL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NUMBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 572-600 amino acids from the C-terminal region of human NUMBL.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu NUMBL

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Andere Bezeichnung: NUMBL (NUMBL Produkte)

Synonyme: nbl antikoerper, numb antikoerper, cag3a antikoerper, ctg3a antikoerper, numbr antikoerper, numb-r antikoerper, tnrc23 antikoerper, numblike antikoerper, CAG3A antikoerper, CTG3a antikoerper, NBL antikoerper, NUMB-R antikoerper, NUMBLIKE antikoerper, NUMBR antikoerper, TNRC23 antikoerper, NUMB like, endocytic adaptor protein antikoerper, numb homolog-like L homeolog antikoerper, NUMB-like, endocytic adaptor protein antikoerper, numb-like antikoerper, NUMBL antikoerper, numbl.L antikoerper, Numbl antikoerper

Hintergrund: NUMBL plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Molekulargewicht: 65 kDa

Gen-ID: 9253

UniProt: Q9Y6R0

Pathways: Cell-Cell Junction Organization