STK3 Antikörper (C-Term)

Produktnummer ABIN5537151

Produktdetails anti-STK3 Antikörper

Target: STK3 (serine/threonine Kinase 3 (STK3))

Bindungsspezifität: AA 387-415, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Stk3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of mouse Stk3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu STK3

Target: STK3 (serine/threonine Kinase 3 (STK3))

Andere Bezeichnung: Stk3 (STK3 Produkte)

Synonyme: KRS1 antikoerper, MST2 antikoerper, 0610042I06Rik antikoerper, MST antikoerper, Mst2 antikoerper, Mst3 antikoerper, Ste20 antikoerper, mess1 antikoerper, mst2 antikoerper, xstk3 antikoerper, wu:fc19e11 antikoerper, zgc:55383 antikoerper, serine/threonine kinase 3 antikoerper, serine/threonine kinase 3 S homeolog antikoerper, serine/threonine kinase 3 (STE20 homolog, yeast) antikoerper, STK3 antikoerper, Stk3 antikoerper, stk3.S antikoerper, stk3 antikoerper

Hintergrund: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MST1/MST2 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1.

Molekulargewicht: 57 kDa

Gen-ID: 56274

UniProt: Q9JI10

Pathways: Tube Formation