USP11 Antikörper (N-Term)

Produktnummer ABIN5534778

Produktdetails anti-USP11 Antikörper

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Bindungsspezifität: AA 279-308, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This USP11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-308 amino acids from the N-terminal region of human USP11.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu USP11

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Andere Bezeichnung: USP11 (USP11 Produkte)

Synonyme: USP11 antikoerper, DKFZp459L098 antikoerper, UHX1 antikoerper, 6230415D12Rik antikoerper, mKIAA4085 antikoerper, Uhx1 antikoerper, ubiquitin specific peptidase 11 antikoerper, universal stress protein antikoerper, USP11 antikoerper, RR_RS19935 antikoerper, Usp11 antikoerper

Hintergrund: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Molekulargewicht: 110 kDa

Gen-ID: 8237

UniProt: P51784