CRY1 Antikörper (C-Term)

Produktnummer ABIN5534081

Produktdetails anti-CRY1 Antikörper

Target: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Bindungsspezifität: AA 556-586, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRY1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This Cry1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 556-586 amino acids from the C-terminal region of human Cry1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CRY1

Target: CRY1 (Cryptochrome 1 (Photolyase-Like) (CRY1))

Andere Bezeichnung: Cry1 (CRY1 Produkte)

Synonyme: cry1-A antikoerper, CRY1 antikoerper, cry2 antikoerper, phll1 antikoerper, xCRY1 antikoerper, PHLL1 antikoerper, AU020726 antikoerper, AU021000 antikoerper, Phll1 antikoerper, ATCRY1 antikoerper, BLU1 antikoerper, BLUE LIGHT UNINHIBITED 1 antikoerper, CRYPTOCHROME 1 APOPROTEIN (BLUE LIGHT PHOTORECEPTOR antikoerper, ELONGATED HYPOCOTYL 4 antikoerper, HY4 antikoerper, OOP2 antikoerper, OUT OF PHASE 2 antikoerper, T3H13.14 antikoerper, T3H13_14 antikoerper, cryptochrome 1 antikoerper, cryptochrome circadian clock 1 L homeolog antikoerper, cryptochrome circadian regulator 1 antikoerper, cryptochrome circadian clock 1 antikoerper, Cryptochrome-1 antikoerper, cryptochrome 1 antikoerper, cryptochrome 1 (photolyase-like) antikoerper, cry1.L antikoerper, CRY1 antikoerper, cry1 antikoerper, siu50817b antikoerper, Cry1 antikoerper

Hintergrund: Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central ?gears?driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function, in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.

Molekulargewicht: 66 kDa

Gen-ID: 1407

UniProt: Q16526

Pathways: Response to Water Deprivation, Proton Transport