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CSNK2A1/CK II alpha Antikörper (AA 250-284)

CSNK2A1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5533994
  • Target Alle CSNK2A1/CK II alpha (CSNK2A1) Antikörper anzeigen
    CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
    Bindungsspezifität
    • 11
    • 11
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 250-284
    Reaktivität
    • 81
    • 57
    • 53
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 75
    • 6
    Kaninchen
    Klonalität
    • 73
    • 8
    Polyklonal
    Konjugat
    • 51
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CSNK2A1/CK II alpha Antikörper ist unkonjugiert
    Applikation
    • 68
    • 33
    • 23
    • 9
    • 9
    • 8
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CSNK2A1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 250-284 amino acids from the Central region of human CSNK2A1.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CSNK2A1 Primärantikörper
  • Applikationshinweise
    For IHC-P starting dilution is: 1:25

    For WB starting dilution is: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    CSNK2A1/CK II alpha (CSNK2A1) (Casein Kinase 2 alpha 1 (CSNK2A1))
    Andere Bezeichnung
    CSNK2A1 (CSNK2A1 Produkte)
    Synonyme
    CK2A2 antikoerper, CSNK2A1 antikoerper, CK2A1 antikoerper, CKII antikoerper, CSNK2A3 antikoerper, CK2A antikoerper, Ck2a antikoerper, BmCK2a antikoerper, wu:fi38e04 antikoerper, wu:fi38h03 antikoerper, csnk2a1 antikoerper, CK-II antikoerper, CK2 antikoerper, Ckiialpha antikoerper, Csnk2a1-rs4 antikoerper, ck2a1 antikoerper, casein kinase 2 alpha 2 antikoerper, casein kinase 2 alpha 1 antikoerper, casein kinase 2 alpha subunit antikoerper, casein kinase 2, alpha 1 polypeptide antikoerper, CK2 protein kinase alpha 2 antikoerper, casein kinase II alpha subunit antikoerper, Casein kinase II alpha subunit antikoerper, casein kinase 2, alpha 1 polypeptide S homeolog antikoerper, CSNK2A2 antikoerper, CSNK2A1 antikoerper, ck2a antikoerper, Ck2a antikoerper, csnk2a1 antikoerper, cka2 antikoerper, Ckiialpha antikoerper, CK2A1 antikoerper, Csnk2a1 antikoerper, csnk2a1.S antikoerper
    Hintergrund
    Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin- mediated degradation.
    Molekulargewicht
    45 kDa
    Gen-ID
    1457
    UniProt
    P68400
    Pathways
    SARS-CoV-2 Protein Interaktom
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