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HSD11B2 Antikörper (AA 277-306)

HSD11B2 Reaktivität: Human WB, FACS, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5533617
  • Target Alle HSD11B2 Antikörper anzeigen
    HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
    Bindungsspezifität
    • 19
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 277-306
    Reaktivität
    • 45
    • 24
    • 24
    • 16
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 63
    • 4
    • 1
    Kaninchen
    Klonalität
    • 66
    • 2
    Polyklonal
    Konjugat
    • 29
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HSD11B2 Antikörper ist unkonjugiert
    Applikation
    • 54
    • 26
    • 19
    • 17
    • 17
    • 12
    • 7
    • 5
    • 4
    • 3
    • 3
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This HSD11B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-306 amino acids from the Central region of human HSD11B2.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product HSD11B2 Primärantikörper
  • Applikationshinweise
    For WB starting dilution is: 1:1000

    For IHC-P starting dilution is: 1:50~100

    For FACS starting dilution is: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    HSD11B2 (Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
    Andere Bezeichnung
    HSD11B2 (HSD11B2 Produkte)
    Synonyme
    MGC81883 antikoerper, 11-HSD2 antikoerper, AME antikoerper, AME1 antikoerper, HSD11K antikoerper, HSD2 antikoerper, SDR9C3 antikoerper, 11HSD2 antikoerper, HSD11B2 antikoerper, hydroxysteroid (11-beta) dehydrogenase 2 L homeolog antikoerper, hydroxysteroid 11-beta dehydrogenase 2 antikoerper, hsd11b2.L antikoerper, HSD11B2 antikoerper, Hsd11b2 antikoerper
    Hintergrund
    There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
    Molekulargewicht
    44 kDa
    Gen-ID
    3291
    UniProt
    P80365
    Pathways
    Steroid Hormone Biosynthesis, Regulation of Systemic Arterial Blood Pressure by Hormones
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