PSME4 Antikörper (AA 503-535)

Produktnummer ABIN5533127

Produktdetails anti-PSME4 Antikörper

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Bindungsspezifität: AA 503-535

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PSME4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PSME4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 503-535 amino acids from human PSME4.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Referenzen für anti-PSME4 Antikörper (ABIN5533127)

Fu, Liu, Zhang, Jiang, Liu, Luo: "Bortezomib-inducible long non-coding RNA myocardial infarction associated transcript is an oncogene in multiple myeloma that suppresses miR-29b." in: Cell death & disease, Vol. 10, Issue 4, pp. 319, (2019) (PubMed).

Details zu PSME4

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Andere Bezeichnung: PSME4 (PSME4 Produkte)

Synonyme: proteasome activating protein 200 antikoerper, Afu4g11290 antikoerper, An04g05320 antikoerper, AO090003001091 antikoerper, PA200 antikoerper, AA409398 antikoerper, AU041366 antikoerper, TEMO antikoerper, mKIAA0077 antikoerper, proteasome activator subunit 4 antikoerper, proteasome activating protein 200 antikoerper, proteasome (prosome, macropain) activator subunit 4 antikoerper, PSME4 antikoerper, Psme4 antikoerper, PA200 antikoerper, AFUA_4G11290 antikoerper, ANI_1_888184 antikoerper, AOR_1_1944154 antikoerper, TERG_07227 antikoerper, psme4 antikoerper

Hintergrund: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Molekulargewicht: 211 kDa

Gen-ID: 23198

UniProt: Q14997

Pathways: DNA Replication, Synthesis of DNA