SNX6 Antikörper

Produktnummer ABIN5532130

Produktdetails anti-SNX6 Antikörper

Target: SNX6 (Sorting Nexin 6 (SNX6))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNX6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SNX6 antibody is generated from rabbits immunized with human SNX6 recombinant protein.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SNX6

Target: SNX6 (Sorting Nexin 6 (SNX6))

Andere Bezeichnung: SNX6 (SNX6 Produkte)

Synonyme: MGC75952 antikoerper, MGC80251 antikoerper, im:7146294 antikoerper, wu:fa55b10 antikoerper, zgc:110798 antikoerper, MSTP010 antikoerper, TFAF2 antikoerper, 2010006G21Rik antikoerper, 2610032J07Rik antikoerper, 2810425K19Rik antikoerper, AU018928 antikoerper, C85963 antikoerper, sorting nexin 6 antikoerper, sorting nexin 6 L homeolog antikoerper, snx6 antikoerper, snx6.L antikoerper, SNX6 antikoerper, Snx6 antikoerper

Hintergrund: SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

Molekulargewicht: 47 kDa

Gen-ID: 58533

UniProt: Q9UNH7

Pathways: EGFR Signaling Pathway