PAPSS1 Antikörper (C-Term)

Produktnummer ABIN5530217

Produktdetails anti-PAPSS1 Antikörper

Target: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

Bindungsspezifität: AA 592-624, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAPSS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This PAPSS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 592-624 amino acids from the C-terminal region of human PAPSS1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu PAPSS1

Target: PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate Synthase 1 (PAPSS1))

Andere Bezeichnung: PAPSS1 (PAPSS1 Produkte)

Synonyme: ATPSK1 antikoerper, PAPSS antikoerper, SK1 antikoerper, AI325286 antikoerper, Asapk antikoerper, papss1 antikoerper, MGC82588 antikoerper, atpsk1 antikoerper, papss antikoerper, sk1 antikoerper, PAPSS1 antikoerper, wu:fc43e12 antikoerper, zgc:194984 antikoerper, zgc:194985 antikoerper, CG8363 antikoerper, DmPAPSS antikoerper, Dmel\\CG8363 antikoerper, PAPS antikoerper, Paps antikoerper, l(3)76BDn antikoerper, paps antikoerper, 3'-phosphoadenosine 5'-phosphosulfate synthase 1 antikoerper, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 antikoerper, bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 antikoerper, PAPS synthetase antikoerper, PAPSS1 antikoerper, Papss1 antikoerper, papss1 antikoerper, papss1.L antikoerper, LOC100543301 antikoerper, LOC100637112 antikoerper, Papss antikoerper

Hintergrund: Sulfotransferase (SULT) enzymes catalyze the sulfate conjugation of many drugs, xenobiotic compounds, hormones, and neurotransmitters. 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase (PAPSS) catalyzes the biosynthesis of PAPS which serves as the universal sulfonate donor compound for all sulfotransferase reactions. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (603005). Bifunctional PAPSS1 is comprised of an N-terminal APS kinase domain, and a C-terminal ATP sulfurylase domain. Full-length protein has significantly less APS kinase activity than the N-terminal fragment, suggesting that the C-terminal domain exerts a regulatory role on the N-terminal APS kinase activity. In humans there are two major isoforms: PAPSS1 and PAPSS2. In brain and skin PAPSS1 is the major isoform, whereas in liver, cartilage and adrenal glands PAPSS2 isoform expression dominates. The predicted 623-amino acid protein is 98 % identical to mouse PAPS synthase. The N-terminal 268-amino acid region of human PAPS synthase resembles APS kinases from other organisms and contains 3 conserved nucleotide-binding motifs.

Molekulargewicht: 71 kDa

Gen-ID: 9061

UniProt: O43252

Pathways: Glycosaminoglycan Metabolic Process, Ribonucleoside Biosynthetic Process