IL1RN Antikörper (AA 26-177)

Produktnummer ABIN5518923

Produktdetails anti-IL1RN Antikörper

Target: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Bindungsspezifität: AA 26-177

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IL1RN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: Rabbit IgG polyclonal antibody for Interleukin-1 receptor antagonist protein(IL1RN) detection. Tested with WB, ELISA in Human.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Interleukin-1 receptor antagonist protein(IL1RN) detection. Tested with WB, ELISA in Human.
Gene Name: interleukin 1 receptor antagonist
Protein Name: Interleukin-1 receptor antagonist protein

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human IL1RA recombinant protein (Position: R26-E177). Human IL1RA shares 77% and 75.5% amino acid (aa) sequence identity with mouse and rat IL1RA, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
ELISA: Concentration: 0.1-0.5 μg/mL, Tested Species: Human

Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ABIN921124) for Western blot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-IL1RN Antikörper (ABIN5518923)

Lu, Jiang, Cao, Zhang, Zhang, Ji, Gao: "TRAF6 upregulation in spinal astrocytes maintains neuropathic pain by integrating TNF-α and IL-1β signaling." in: Pain, Vol. 155, Issue 12, pp. 2618-29, (2015) (PubMed).

Details zu IL1RN

Target: IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Andere Bezeichnung: IL1RN (IL1RN Produkte)

Synonyme: DIRA antikoerper, ICIL-1RA antikoerper, IL-1RN antikoerper, IL-1ra antikoerper, IL-1ra3 antikoerper, IL1F3 antikoerper, IL1RA antikoerper, IRAP antikoerper, MVCD4 antikoerper, IRAP1 antikoerper, IL1RN antikoerper, IL-1RA antikoerper, F630041P17Rik antikoerper, interleukin 1 receptor antagonist antikoerper, interleukin 1 receptor antagonist-like antikoerper, IL1RN antikoerper, Il1rn antikoerper, IL1RNL antikoerper

Hintergrund: The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.

Synonyms: Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra, IL1RN, IL1F3, IL1RA

Gen-ID: 3557

UniProt: P18510

Pathways: NF-kappaB Signalweg, Hormone Transport, Cancer Immune Checkpoints