MC1 Receptor Antikörper (C-Term)

Produktnummer ABIN5518773

Produktdetails anti-MC1 Receptor Antikörper

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Bindungsspezifität: AA 290-317, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MC1 Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Melanocyte-stimulating hormone receptor(MC1R) detection. Tested with WB in Human,Mouse,Rat.

Sequenz: NAIIDPLIYA FHSQELRRTL KEVLTCSW

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Melanocyte-stimulating hormone receptor(MC1R) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: melanocortin 1 receptor
Protein Name: Melanocyte-stimulating hormone receptor

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MC1 Receptor (290-317aa NAIIDPLIYAFHSQELRRTLKEVLTCSW).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Andere Bezeichnung: MC1R (MC1R Produkte)

Synonyme: CMM5 antikoerper, MSH-R antikoerper, SHEP2 antikoerper, Mshra antikoerper, Tob antikoerper, e antikoerper, MC1-R antikoerper, MSHR antikoerper, mc1r antikoerper, MC1R antikoerper, TUBB3 antikoerper, melanocortin 1 receptor antikoerper, melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) antikoerper, MC1R antikoerper, Mc1r antikoerper, mc1r antikoerper, mc1r_par1 antikoerper

Hintergrund: The melanocortin 1 receptor (MC1R), mapped to 16q24.3, is also known as MSHR. This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

Synonyms: CMM5 | MC1-R | MC1R | MSH-R | MSHR | SHEP2 | Q01726

Gen-ID: 4157

UniProt: Q01726

Pathways: cAMP Metabolic Process, Feeding Behaviour