ABCC4 Antikörper (AA 1-77)

Produktnummer ABIN5518719

Produktdetails anti-ABCC4 Antikörper

Target: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Bindungsspezifität: AA 1-77

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABCC4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB in Human.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4(ABCC4) detection. Tested with WB in Human.
Gene Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Protein Name: Multidrug resistance-associated protein 4

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human MRP4 recombinant protein (Position: M1-K77).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu ABCC4

Target: ABCC4 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))

Andere Bezeichnung: ABCC4 (ABCC4 Produkte)

Synonyme: EST170205 antikoerper, MOAT-B antikoerper, MOATB antikoerper, MRP4 antikoerper, D630049P08Rik antikoerper, Mrp4 antikoerper, ATP binding cassette subfamily C member 4 antikoerper, multidrug resistance-associated protein 4 antikoerper, ATP-binding cassette, sub-family C (CFTR/MRP), member 4 antikoerper, ABCC4 antikoerper, LOC515333 antikoerper, LOC616707 antikoerper, LOC695407 antikoerper, abcc4 antikoerper, Abcc4 antikoerper

Hintergrund: ABCC4(Atp-binding cassette, subfamily c, member 4), also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

Synonyms: ABCC4 | MOATB | MOAT-B | MRP4 | O15439

Gen-ID: 10257

UniProt: O15439