Angiotensin I Converting Enzyme 1 Antikörper (N-Term)

Produktnummer ABIN5518713

Produktdetails anti-Angiotensin I Converting Enzyme 1 Antikörper

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Bindungsspezifität: AA 130-144, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Angiotensin I Converting Enzyme 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Angiotensin-converting enzyme(ACE) detection. Tested with WB in Human,Mouse.

Sequenz: ANLPLAKRQQ YNALL

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Angiotensin-converting enzyme(ACE) detection. Tested with WB in Human,Mouse.
Gene Name: angiotensin I converting enzyme
Protein Name: Angiotensin-converting enzyme

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Angiotensin Converting Enzyme 1(130-144aa ANLPLAKRQQYNALL), different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-Angiotensin I Converting Enzyme 1 Antikörper (ABIN5518713)

Yan, Shen: "Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system." in: Molecular medicine reports, Vol. 16, Issue 4, pp. 3965-3973, (2018) (PubMed).

Details zu Angiotensin I Converting Enzyme 1

Target: Angiotensin I Converting Enzyme 1 (ACE) (Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 1 (ACE))

Andere Bezeichnung: ACE (ACE Produkte)

Synonyme: ACE1 antikoerper, CD143 antikoerper, DCP antikoerper, DCP1 antikoerper, ICH antikoerper, MVCD3 antikoerper, AW208573 antikoerper, Dcp1 antikoerper, StsRR92 antikoerper, dcp antikoerper, ace1 antikoerper, dcp1 antikoerper, xace antikoerper, cd143 antikoerper, ACE antikoerper, angiotensin I converting enzyme antikoerper, angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 antikoerper, angiotensin-converting enzyme antikoerper, angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 antikoerper, angiotensin-converting enzyme-like antikoerper, ACE antikoerper, Ace antikoerper, ace antikoerper, CpipJ_CPIJ009106 antikoerper, ACE3 antikoerper, LOC101824864 antikoerper

Hintergrund: Angiotensin I converting enzyme(ACE), also called DCP or CD143 is a zinc-containing dipeptidyl carboxypeptidase widely distributed in mammalian tissues and is though to play a critical role in blood pressure regulation. This gene is mapped to 17q23.3. This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies.

Synonyms: ACE 1 antibody|ACE antibody|ACE T antibody|ACE_HUMAN antibody|ACE1 antibody|Angiotensin converting enzyme somatic isoform antibody|Angiotensin converting enzyme testis specific isoform antibody|Angiotensin I converting enzyme 1 antibody|Angiotensin I converting enzyme antibody|Angiotensin I converting enzyme peptidyl dipeptidase A 1 antibody|Angiotensin-converting enzyme antibody|Carboxycathepsin antibody|CD 143 antibody|CD143 antibody|CD143 antigen antibody|DCP 1 antibody|DCP antibody|DCP1 antibody|Dipeptidyl carboxypeptidase 1 antibody|Dipeptidyl carboxypeptidase I antibody|Kininase II antibody|MGC26566 antibody|MVCD3 antibody|Peptidase P antibody|Peptidyl dipeptidase A antibody|soluble form antibody|Testicular ECA antibody

UniProt: P12821

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration