NTRK3 Antikörper (N-Term)

Produktnummer ABIN5518697

Produktdetails anti-NTRK3 Antikörper

Target: NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))

Bindungsspezifität: AA 167-182, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NTRK3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for NT-3 growth factor receptor(NTRK3) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: DIRWMQLWQE QGEAKL

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for NT-3 growth factor receptor(NTRK3) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: neurotrophic tyrosine kinase, receptor, type 3
Protein Name: NT-3 growth factor receptor

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human TrkC(167-182aa DIRWMQLWQEQGEAKL), different from the related mouse and rat sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for NTRK3 is approximately 3 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu NTRK3

Target: NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))

Andere Bezeichnung: NTRK3 (NTRK3 Produkte)

Synonyme: TRKC antikoerper, gp145(trkC) antikoerper, trkC antikoerper, AW125844 antikoerper, Ntrk3_tv3 antikoerper, TrkC antikoerper, neurotrophic receptor tyrosine kinase 3 antikoerper, neurotrophic tyrosine kinase, receptor, type 3 antikoerper, NTRK3 antikoerper, Ntrk3 antikoerper

Hintergrund: NTRK3(Neurotrophic Tyrosine Kinase Receptor Type 3), also known as TRKC, is a protein that in humans is encoded by the NTRK3 gene. By PCR analysis of a somatic cell hybrid panel and by fluorescence in situ hybridization with the cDNA clone, McGregor et al.(1994) mapped the NTRK3 gene to 15q24-q25. Lamballe et al.(1991) isolated and characterized TRKC, a member of the TRK family of tyrosine protein kinase genes. They found that TRKC is preferentially expressed in the brain, in situ hybridization studies showed transcripts in the hippocampus, cerebral cortex, and the granular cell layer of the cerebellum. By functional studies in HeLa cells, Muinos-Gimeno et al.(2009) demonstrated that 5 miRNAs regulate the truncated form of NTRK3.

Synonyms: EC 2.7.10.1 antibody|ETS related protein neurotrophic receptor tyrosine kinase fusion antibody|ETV6 NTRK3 fusion antibody|GP145 TrkC antibody|gp145(trkC) antibody|GP145-TrkC antibody|GP145TrkC antibody|Neurotrophic tyrosine kinase receptor type 3 antibody|Neurotrophin 3 receptor antibody|NT 3 growth factor receptor antibody|NT 3 growth factor receptor precursor antibody|NT 3 receptor antibody|NT-3 growth factor receptor antibody|Ntrk3 antibody|NTRK3_HUMAN antibody|OTTHUMP00000192915 antibody|TRK C antibody|Trk-C antibody|TrkC tyrosine kinase antibody|Tyrosine kinase receptor C antibody

UniProt: Q16288

Pathways: RTK Signalweg, Neurotrophin Signalübertragung, Regulation of Cell Size