NR1H3 Antikörper (C-Term)
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- Target Alle NR1H3 Antikörper anzeigen
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
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Bindungsspezifität
- AA 371-385, C-Term
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NR1H3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Verwendungszweck
- Rabbit IgG polyclonal antibody for Oxysterols receptor LXR-alpha(NR1H3) detection. Tested with WB in Human,Mouse,Rat.
- Sequenz
- NVQDQLQVER LQHTY
- Kreuzreaktivität (Details)
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Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities. - Produktmerkmale
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Rabbit IgG polyclonal antibody for Oxysterols receptor LXR-alpha(NR1H3) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: nuclear receptor subfamily 1, group H, member 3
Protein Name: Oxysterols receptor LXR-alpha - Aufreinigung
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence at the C-terminus of human LXR alpha(371-385aa NVQDQLQVERLQHTY), identical to the related rat and mouse sequences.
- Isotyp
- IgG
- Top Product
- Discover our top product NR1H3 Primärantikörper
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- Applikationshinweise
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Kommentare
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Konzentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- Konservierungsmittel
- Sodium azide, Thimerosal (Merthiolate)
- Vorsichtsmaßnahmen
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 503-8, (2014) (PubMed).
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Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells." in: Molecular medicine reports, Vol. 11, Issue 1, pp. 503-8, (2014) (PubMed).
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- Target
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
- Andere Bezeichnung
- NR1H3 (NR1H3 Produkte)
- Synonyme
- NR1H3 antikoerper, LXR-a antikoerper, LXRA antikoerper, RLD-1 antikoerper, AU018371 antikoerper, LXR antikoerper, RLD1 antikoerper, Unr1 antikoerper, LXRalpha antikoerper, LXR-alpha antikoerper, im:7141239 antikoerper, wu:fd59b01 antikoerper, zgc:113339 antikoerper, zgc:158542 antikoerper, nuclear receptor subfamily 1 group H member 3 antikoerper, nuclear receptor subfamily 1, group H, member 3 antikoerper, NR1H3 antikoerper, nr1h3 antikoerper, Nr1h3 antikoerper
- Hintergrund
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LXRA is a tissue-specific cofactor that permits RXRA to function as a potent 9cRA receptor with a distinct target gene specificity. It specifically interacts with RXRA in vivo to form a functional heterodimer in which RXRA is the ligand-binding subunit. Additionally, LXR activity is critical for physiologic lipid metabolism and transport. LXRs are endogenous inhibitors of atherogenesis and are targets for therapeutic intervention in cardiovascular disease. Furthermore, LXRs and their ligands are negative regulators of macrophage inflammatory gene expression. LXR is also found that as a transcriptional switch that integrates hepatic glucose metabolism and fatty acid synthesis. The LXR-IDOL-LDLR axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake.
Synonyms: Liver X receptor alpha antibody|LXR a antibody|LXRA antibody|NR1H3 antibody|NR1H3_HUMAN antibody|Nuclear orphan receptor LXR alpha antibody|Nuclear receptor subfamily 1 group H member 3 antibody|Oxysterols receptor LXR alpha antibody|Oxysterols receptor LXR-alpha antibody|RLD 1 antibody|RLD1 antibody - UniProt
- Q13133
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding, Cellular Response to Molecule of Bacterial Origin, Hepatitis C
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