SPATA18 Antikörper (Middle Region)

Produktnummer ABIN5517765

Produktdetails anti-SPATA18 Antikörper

Target: SPATA18 (Spermatogenesis Associated 18 (SPATA18))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SPATA18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: ELKSLQAQED ARHRNTDQRS SENRRSEPWS LEERKREQWN SLKQNADQQD

Homologie: Cow: 77%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against SPATA18. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human SPATA18

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu SPATA18

Target: SPATA18 (Spermatogenesis Associated 18 (SPATA18))

Andere Bezeichnung: SPATA18 (SPATA18 Produkte)

Synonyme: Mieap antikoerper, SPETEX1 antikoerper, 1700067I02Rik antikoerper, MIEAP antikoerper, spetex-1 antikoerper, mieap antikoerper, spetex1 antikoerper, im:7140046 antikoerper, zgc:110352 antikoerper, spermatogenesis associated 18 antikoerper, spermatogenesis associated 18 L homeolog antikoerper, SPATA18 antikoerper, Spata18 antikoerper, spata18.L antikoerper, spata18 antikoerper

Hintergrund: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.

Alias Symbols: Mieap, SPETEX1

Protein Interaction Partner: PAXIP1,

Protein Size: 506

Gen-ID: 132671

NCBI Accession: NM_001297608, NP_001284537