Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

HMGCR Antikörper (Middle Region)

HMGCR Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5516967
  • Target Alle HMGCR Antikörper anzeigen
    HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
    Bindungsspezifität
    • 16
    • 16
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 60
    • 48
    • 46
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 59
    • 3
    • 1
    Kaninchen
    Klonalität
    • 49
    • 14
    Polyklonal
    Konjugat
    • 21
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser HMGCR Antikörper ist unkonjugiert
    Applikation
    • 49
    • 29
    • 26
    • 26
    • 13
    • 8
    • 8
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    TLMETHERGV SIRRQLLSKK LSEPSSLQYL PYRDYNYSLV MGACCENVIG
    Aufreinigung
    Affinity purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human HMGCR
    Top Product
    Discover our top product HMGCR Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
    Andere Bezeichnung
    HMGCR (HMGCR Produkte)
    Synonyme
    HMGR antikoerper, LDLCQ3 antikoerper, hmg-coa-r antikoerper, HMG-CoAR antikoerper, Red antikoerper, 3H3M antikoerper, BcDNA:LD15354 antikoerper, CG10367 antikoerper, Clb antikoerper, DmHMG-CoAr antikoerper, Dmel\\CG10367 antikoerper, HMGCR antikoerper, HMGCR_Dm antikoerper, HMGCoAR antikoerper, HMGCoARr antikoerper, HMGCoAr antikoerper, HmG-CoAR antikoerper, Hmg antikoerper, bro1 antikoerper, bs32f05.y1 antikoerper, clb antikoerper, hmgc antikoerper, hmgcr antikoerper, hmgrc antikoerper, l(3)01152 antikoerper, l(3)04684 antikoerper, hmgcr2 antikoerper, im:6912716 antikoerper, zgc:110746 antikoerper, 3-hydroxy-3-methylglutaryl-CoA reductase antikoerper, 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog antikoerper, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antikoerper, HMG Coenzyme A reductase antikoerper, 3-hydroxy-3-methylglutaryl-CoA reductase b antikoerper, HMGCR antikoerper, hmgcr.L antikoerper, Hmgcr antikoerper, hmgcrb antikoerper
    Hintergrund
    HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

    Alias Symbols: LDLCQ3

    Protein Size: 888
    Gen-ID
    3156
    NCBI Accession
    NM_000859, NP_000850
    UniProt
    P04035
    Pathways
    AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
Sie sind hier:
Kundenservice