INSIG1 Antikörper (Middle Region)

Produktnummer ABIN5516805

Produktdetails anti-INSIG1 Antikörper

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INSIG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LAAHGAPDAD PAPRGRSAAM SGPEPGSPYP NTWHHRLLQR SLVLFSVGVV

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human INSIG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 16 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu INSIG1

Target: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Andere Bezeichnung: INSIG1 (INSIG1 Produkte)

Synonyme: cl-6 antikoerper, cl6 antikoerper, CL-6 antikoerper, CL6 antikoerper, fb55a03 antikoerper, fi35b10 antikoerper, wu:fb55a03 antikoerper, wu:fi35b10 antikoerper, zgc:55439 antikoerper, 1810013C12Rik antikoerper, Insig-1 antikoerper, INSIG-1 antikoerper, insulin induced gene 1 antikoerper, insulin induced gene 1 L homeolog antikoerper, INSIG1 antikoerper, insig1 antikoerper, insig1.L antikoerper, Insig1 antikoerper

Hintergrund: Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alias Symbols: CL6, CL-6,

Protein Size: 277

Gen-ID: 3638

NCBI Accession: NM_005542, NP_005533

UniProt: O15503

Pathways: ER-Nucleus Signaling