WWTR1 Antikörper (C-Term)

Produktnummer ABIN5516208

Produktdetails anti-WWTR1 Antikörper

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WWTR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PPTMTPDMRS ITNNSSDPFL NGGPYHSREQ STDSGLGLGC YSVPTTPEDF

Produktmerkmale: This is a rabbit polyclonal antibody against WWTR1. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of Human WWTR1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu WWTR1

Target: WWTR1 (WW Domain Containing Transcription Regulator 1 (WWTR1))

Andere Bezeichnung: WWTR1 (WWTR1 Produkte)

Synonyme: WWTR1 antikoerper, TAZ antikoerper, 2310058J06Rik antikoerper, 2610021I22Rik antikoerper, C78399 antikoerper, Taz antikoerper, WW domain containing transcription regulator 1 L homeolog antikoerper, WW domain containing transcription regulator 1 antikoerper, wwtr1.L antikoerper, wwtr1 antikoerper, WWTR1 antikoerper, Wwtr1 antikoerper

Hintergrund: WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. It regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. And it regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Alias Symbols: WWTR1, TAZ,

Protein Interaction Partner: MED28, NOTCH1, YWHAQ, LATS1, BTRC, YWHAE, TP53BP2, PPP1CA, KLF5, YWHAZ, YWHAG, PAX3, SLC9A3R2, TEAD3, TEAD4, NKX2-1, RUNX1,

Protein Size: 400

Gen-ID: 25937

NCBI Accession: NP_056287

UniProt: Q9GZV5

Pathways: Regulation of Lipid Metabolism by PPARalpha