FE65 Antikörper (N-Term)

Produktnummer ABIN5515785

Produktdetails anti-FE65 Antikörper

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FE65 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: QALTDGPREH SKSASLLFGM RNSAASDEDS SWATLSQGSP SYGSPEDTDS

Produktmerkmale: This is a rabbit polyclonal antibody against APBB1. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human APBB1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu FE65

Target: FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))

Andere Bezeichnung: APBB1 (APBB1 Produkte)

Synonyme: FE65 antikoerper, MGC:9072 antikoerper, RIR antikoerper, apbb1 antikoerper, MGC80654 antikoerper, Fe65 antikoerper, Rir antikoerper, amyloid beta precursor protein binding family B member 1 antikoerper, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog antikoerper, amyloid beta (A4) precursor protein-binding, family B, member 1 antikoerper, APBB1 antikoerper, apbb1.L antikoerper, Apbb1 antikoerper

Hintergrund: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alias Symbols: APBB1, FE65, RIR,

Protein Size: 710

Gen-ID: 322

UniProt: O00213

Pathways: Positive Regulation of Response to DNA Damage Stimulus