C14orf169 + NO66 Antikörper (Middle Region)

Produktnummer ABIN5514591

Produktdetails anti-C14orf169 + NO66 Antikörper

Target: C14orf169 + NO66 (C14orf169) (Chromosome 14 Open Reading Frame 169 (C14orf169))

Bindungsspezifität: Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser C14orf169 + NO66 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: EAILPLAVQA AMEENVEFRR GLPRDFMDYM GAQHSDSKDP RRTAFMEKVR

Produktmerkmale: This is a rabbit polyclonal antibody against NO66. It was validated on Western Blot.

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human NO66

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu C14orf169 + NO66

Target: C14orf169 + NO66 (C14orf169) (Chromosome 14 Open Reading Frame 169 (C14orf169))

Andere Bezeichnung: NO66 (C14orf169 Produkte)

Hintergrund: NO66 is an oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically It demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). It also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). It may also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region.

Alias Symbols: NO66, C14orf169, MAPJD,

Protein Interaction Partner: KAT5, TRRAP, MYC, USP42,

Protein Size: 429

Gen-ID: 79697