RAGE Antikörper (Middle Region)

Produktnummer ABIN548553

Produktdetails anti-RAGE Antikörper

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAGE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit polyclonal antibody raised against synthetic peptide of AGER.

Spezifität: The synthetic peptide of this antibody different from the mouse and rat sequence by two amino acids.

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Immunogen: A synthetic peptide corresponding to amino acids at middle region of human AGER.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot (1 μg/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1 μg/mL)
The optimal working dilution should be determined by the end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from 0.9 mg NaCl, 0.2 mg Na₂HPO₄ (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.

Referenzen für anti-RAGE Antikörper (ABIN548553)

Bierhaus, Haslbeck, Humpert, Liliensiek, Dehmer, Morcos, Sayed, Andrassy, Schiekofer, Schneider, Schulz, Heuss, Neundörfer, Dierl, Huber, Tritschler, Schmidt, Schwaninger, Haering, Schleicher, Kasper et al.: "Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. ..." in: The Journal of clinical investigation, Vol. 114, Issue 12, pp. 1741-51, (2004) (PubMed).

Chavakis, Bierhaus, Al-Fakhri, Schneider, Witte, Linn, Nagashima, Morser, Arnold, Preissner, Nawroth: "The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment." in: The Journal of experimental medicine, Vol. 198, Issue 10, pp. 1507-15, (2003) (PubMed).

Taguchi, Blood, del Toro, Canet, Lee, Qu, Tanji, Lu, Lalla, Fu, Hofmann, Kislinger, Ingram, Lu, Tanaka, Hori, Ogawa, Stern, Schmidt: "Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases." in: Nature, Vol. 405, Issue 6784, pp. 354-60, (2000) (PubMed).

Details zu RAGE

Target: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Andere Bezeichnung: RAGE / AGER (AGER Produkte)

Synonyme: RAGE antikoerper, AGER antikoerper, advanced glycosylation end-product specific receptor antikoerper, advanced glycosylation end product-specific receptor antikoerper, MAPK/MAK/MRK overlapping kinase antikoerper, AGER antikoerper, Ager antikoerper, LOC719012 antikoerper

Gen-ID: 177

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteine