LASS5
Reaktivität: Human
ELISA
Wirt: Kaninchen
Polyclonal
Biotin
Applikationshinweise
Western Blot (1-2 μg/mL) The optimal working dilution should be determined by the end user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
In PBS (0.02 % sodium azide)
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Informationen zur Lagerung
Store at 4°C for three months. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells." in: Anticancer research, Vol. 32, Issue 3, pp. 753-60, (2012) (PubMed).
Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy." in: Anticancer research, Vol. 32, Issue 7, pp. 2479-85, (2012) (PubMed).
Spassieva, Seo, Jiang, Bielawski, Alvarez-Vasquez, Jazwinski, Hannun, Obeid: "Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 33931-8, (2006) (PubMed).
Lahiri, Futerman: "LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor." in: The Journal of biological chemistry, Vol. 280, Issue 40, pp. 33735-8, (2005) (PubMed).
Riebeling, Allegood, Wang, Merrill, Futerman: "Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43452-9, (2003) (PubMed).