Mouse monoclonal antibody raised against native CD72.
Spezifität
This antibody 3F3 reacts with CD72, a 39-43 KDa type II membrane glycoprotein (C-type lectin family). CD72 is a pan-B cell marker expressed throughout the B lymphocytes diferentiation with the exception of plasma cells, it is also present on follicular dendritic cells.
Kreuzreaktivität
Human
Immunogen
Native purified CD72 from normal human lymphocytes from lymph node.
CD72
Reaktivität: Human
FACS
Wirt: Maus
Monoclonal
3F3
PE
Applikationshinweise
Flow Cytometry (20 µL in human blood cells 100 µL in whole blood or 106 cells in a suspension) The optimal working dilution should be determined by the end user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
In PBS (0.2 % BSA, 0.09 % sodium azide)
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store in the dark at 4°C. Do not freeze. Avoid prolonged exposure to light. Aliquot to avoid repeated freezing and thawing.
Mizrahi, Markel, Porgador, Bushkin, Mandelboim: "CD100 on NK cells enhance IFNgamma secretion and killing of target cells expressing CD72." in: PLoS ONE, Vol. 2, Issue 9, pp. e818, (2007) (PubMed).
Kumanogoh, Shikina, Watanabe, Takegahara, Suzuki, Yamamoto, Takamatsu, Prasad, Mizui, Toyofuku, Tamura, Watanabe, Parnes, Kikutani: "Requirement for CD100-CD72 interactions in fine-tuning of B-cell antigen receptor signaling and homeostatic maintenance of the B-cell compartment." in: International immunology, Vol. 17, Issue 10, pp. 1277-82, (2005) (PubMed).
Kumanogoh, Kikutani: "The CD100-CD72 interaction: a novel mechanism of immune regulation." in: Trends in immunology, Vol. 22, Issue 12, pp. 670-6, (2001) (PubMed).