MERS-Coronavirus Spike Antikörper

Produktnummer ABIN5027657

Produktdetails anti-MERS-Coronavirus Spike Antikörper

Target: MERS-Coronavirus Spike (MERS-CoV S) (MERS-Coronavirus Spike Protein (MERS-CoV S))

Reaktivität: Middle East Respiratory Syndrome Coronavirus (MERS-CoV)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MERS-Coronavirus Spike Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein G Chromatography

Immunogen: A recombinant protein fragment of MERS-CoV Spike (S) protein was used as the immunogen for this antibody.

Klon: ABM4A80

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: WB: 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu MERS-Coronavirus Spike

Target: MERS-Coronavirus Spike (MERS-CoV S) (MERS-Coronavirus Spike Protein (MERS-CoV S))

Andere Bezeichnung: MERS-CoV Spike (S) protein (MERS-CoV S Produkte)

Substanzklasse: Viral Protein

Hintergrund: The MERS-CoV spike (S) protein is a type I transmembrane glycoprotein which contains 1353 amino acids and can be cleaved into two subunit S1 and S2. It forms large protruding spikes on the surface of the virus. The S1 subunit which contains RBD is responsible for binding to Dipeptidyl peptidase 4, which serves as the host cell receptor of MERS-CoV and S2 mediates the membrane fusion. In this process, heptad repeats 1 and 2 (HR1 and HR2) of the S protein assemble into a complex called six-helix bundle (6-HB) fusion core structure, which represents a key membrane fusion architecture. Importantly, the S protein is considered a key component of vaccines against coronavirus infection, including severe acute respiratory syndrome (SARS).

Molekulargewicht: 28 kDa

UniProt: W5ZZU6