IKKi/IKKe Antikörper (AA 2-203)

Produktnummer ABIN5027294

Produktdetails anti-IKKi/IKKe Antikörper

Target: IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Bindungsspezifität: AA 2-203

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IKKi/IKKe Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Aufreinigung: Protein G Chromatography

Immunogen: A partial length recombinant Ikke protein (amino acids 2-203) was used as the immunogen for this antibody.

Klon: ABM13C7

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL, IHC: 10-20 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu IKKi/IKKe

Target: IKKi/IKKe (IKBKE) (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE))

Andere Bezeichnung: Ikke/Ikki/TBK1 (IKBKE Produkte)

Synonyme: zgc:100844 antikoerper, IKBKE antikoerper, MGC130907 antikoerper, IKK-E antikoerper, IKK-i antikoerper, IKKE antikoerper, IKKI antikoerper, AW558201 antikoerper, IKKepsilon antikoerper, Ikki antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon antikoerper, inhibitor of nuclear factor kappa B kinase subunit epsilon antikoerper, inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog antikoerper, inhibitor of kappaB kinase epsilon antikoerper, IKBKE antikoerper, ikbke antikoerper, ikbke.L antikoerper, Ikbke antikoerper

Hintergrund: Ikke is a member of the IKK (IKappaB kinase) family that has been identified as an oncogenic protein and found to be up-regulated in breast cancer, ovarian cancer and prostate cancer. The Ikke protein has 33 % and 31 % identity at the amino acid level with Ikka and Ikkb, respectively and is primarily activated by interferon and mediates interferon signaling. The activated Ikke stimulates the transcription factor interferon regulatory factors 3 and phosphorylates signal transducer and activator of transcription. Ikke also shares some function with Ikka and Ikkb to activate NF- KappaB pathway by phosphorylation and degradation of IKappaBalpha. However, Ikke mainly mediates NF-KappaB activation induced by interferon, phorbol 12-myristate 13-acetate or the T-cell receptor, but not by tumor necrosis factor and interleukin 1, which activate Ikka and Ikkb. Ikke is predominantly expressed and active in peripheral blood leukocytes, pancreas, thymus, and spleen and contributes to IRF as well as NF-KappaB activation.

Molekulargewicht: 76

Gen-ID: 9641

UniProt: Q14164

Pathways: TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades