DACT1 Antikörper (AA 645-820)

Produktnummer ABIN5027132

Produktdetails anti-DACT1 Antikörper

Target: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Bindungsspezifität: AA 645-820

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DACT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Protein A Chromatography

Immunogen: A partial length recombinant Dapper homolog 1 protein (amino acids 645-820) was used as the immunogen for this antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 2-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % BSA, PH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

Details zu DACT1

Target: DACT1 (Dapper, Antagonist of beta-Catenin, Homolog 1 (DACT1))

Andere Bezeichnung: Dapper homolog 1 (DACT1 Produkte)

Synonyme: XDpr antikoerper, dpr1 antikoerper, frodo antikoerper, hdpr1 antikoerper, Dapper antikoerper, thyex3 antikoerper, dapper1 antikoerper, MGC89695 antikoerper, frd1 antikoerper, frodo1 antikoerper, 4921528D17Rik antikoerper, AI115603 antikoerper, DAPPER antikoerper, DAPPER1 antikoerper, FRODO antikoerper, Frd1 antikoerper, Frodo1 antikoerper, MDpr1 antikoerper, MTNG3 antikoerper, THYEX3 antikoerper, DPR1 antikoerper, HDPR1 antikoerper, DACT1 antikoerper, RGD1564008 antikoerper, XDpr1a antikoerper, dact1 antikoerper, dpr antikoerper, XDpr1b antikoerper, dishevelled-binding antagonist of beta-catenin 1 antikoerper, dishevelled binding antagonist of beta catenin 1 antikoerper, dishevelled-binding antagonist of beta-catenin 1 L homeolog antikoerper, dishevelled-binding antagonist of beta-catenin 1 S homeolog antikoerper, dact1 antikoerper, Dact1 antikoerper, DACT1 antikoerper, dact1.L antikoerper, dact1.S antikoerper

Hintergrund: Dapper homolog 1 (DACT1) is a cytoplasmic protein and a member of DACT family. It is an important regulator in the planar cell polarity (PCP) pathway. DACT1 interacts and posttranslationally regulates central PCP components Dvl2 and Vangl2 and modulates PCP downstream of the Rac1/JNK cascade. The gene for DACT1 is located at chromosome 14q22.3, which encodes a 836 amino acid protein with a putative leucine zipper (LZ) domain in the amino-terminal end and a consensus PDZ binding (PDZ-B) motif in the carboxy-terminal end that allows the DACT1 protein to interact with the Dishevelled (Dvl) PDZ domain. DACT1 is an important positive regulator in colon cancer through regulating the stability and sublocation of Beta-catenin. The overexpression of DACT1 leads to the increased accumulation of nonphosphorylated Beta-catenin in the cytoplasm and particularly in the nuclei.It interacts with GSK-3beta and beta-catenin and stabilizes it via DACT1-induced effects on GSK-3beta which directly interacts with beta-catenin proteins. This interaction identifies DACT1 as an important positive regulator in colon cancer and suggests a potential strategy for the therapeutic control of the beta-catenin-dependent pathway.

Molekulargewicht: 92 kDa

Gen-ID: 51339

UniProt: Q9NYF0

Pathways: Positive Regulation of fat Cell Differentiation