AXL Antikörper (AXL Receptor tyrosine Kinase) (AA 33-440)

Details for Product anti-AXL Antibody No. ABIN5012837, Anbieter: Anmelden zum Anzeigen
Antigen
  • JTK11
  • UFO
  • AI323647
  • Ark
  • Tyro7
  • Ufo
  • AXL receptor tyrosine kinase
  • Axl receptor tyrosine kinase
  • AXL
  • Axl
Epitop
AA 33-440
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11
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1
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Reaktivität
Human
260
106
71
5
2
2
1
1
1
1
Wirt
Ziege
181
91
27
1
1
Klonalität
Polyklonal
Konjugat
Dieser AXL Antikörper ist unkonjugiert
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12
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11
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2
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1
Applikation
Blocking Reagent (BR), Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Western Blotting (WB)
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69
28
26
18
9
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Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Mouse myeloma cell line NS0-derived recombinant human Axl, Glu33-Pro440, Accession # AAA61243
Isotyp IgG
Spezifität Detects human Axl in direct ELISAs and Western blots. In direct ELISAs, less than 25 % cross-reactivity with recombinant mouse Axl is observed.
Reinigung Antigen Affinity-purified
Plasmids, Primers & others Plasmide, Primers & weitere AXL products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Axl (AXL Antibody Abstract)
Hintergrund Alternative Names: Ark, AXL oncogene, AXL receptor tyrosine kinase, AXL transforming sequence/gene, EC 2.7.10, EC 2.7.10.1, JTK11, tyrosine-protein kinase receptor UFO, Ufo, UFOoncogene AXL
Gen-ID 558
Pathways RTK Signalweg, Cellular Response to Molecule of Bacterial Origin
Applikations-hinweise Western Blot 1 μg/mL
Flow Cytometry 2.5 μg/10^6 cells
Immunohistochemistry 5-15 μg/mL
Blockade of Receptor-ligand Interaction
CyTOF-ready
Knockout Validated
Beschränkungen Nur für Forschungszwecke einsetzbar
Rekonstitution Reconstitute at 0.2 mg/mL in sterile PBS.
Buffer Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Konservierungs-mittel Without preservative
Lagerung 4 °C,-20 °C,-80 °C
Informationen zur Lagerung Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20°C to -70°C as supplied. 1 month,2°C to 8°C under sterile conditions after reconstitution. 6 months,-20°C to -70°C under sterile conditions after reconstitution.
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-AXL Receptor tyrosine Kinase (AXL) (AA 33-440) antibody (ABIN5012837) Axl in Human Stomach. Axl was detected in immersion fixed paraffin-embedded sections ...
Western Blotting (WB) image for anti-AXL Receptor tyrosine Kinase (AXL) (AA 33-440) antibody (ABIN5012837) Detection of Human Axl by Western Blot. Western blot shows lysates of HeLa human cerv...
Western Blotting (WB) image for anti-AXL Receptor tyrosine Kinase (AXL) (AA 33-440) antibody (ABIN5012837) Western Blot Shows Human Axl Specificity by Using Knockout Cell Line. Western blot sh...
Flow Cytometry (FACS) image for anti-AXL Receptor tyrosine Kinase (AXL) (AA 33-440) antibody (ABIN5012837) Axl Specificity is Shown by Flow Cytometry in Knockout Cell Line. Axl knockout A431 h...
Flow Cytometry (FACS) image for anti-AXL Receptor tyrosine Kinase (AXL) (AA 33-440) antibody (ABIN5012837) Detection of Axl in A431 Human Cell Line by Flow Cytometry. A431 human epithelial car...
Produkt verwendet in: Divine, Nguyen, Meller, Desai, Arif, Rankin, Bligard, Meyerson, Hagemann, Massad, Thaker, Hagemann, McCourt, Powell, Mutch, Fuh: "AXL modulates extracellular matrix protein expression and is essential for invasion and metastasis in endometrial cancer." in: Oncotarget, Vol. 7, Issue 47, pp. 77291-77305, 2018 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (IHC), Immunohistochemistry (IHC) (Probematerial (Species): Human).

Kumar, Jovel, Lopez-Orozco, Limonta, Airo, Hou, Stryapunina, Fibke, Moore, Hobman: "Human Sertoli cells support high levels of Zika virus replication and persistence." in: Scientific reports, Vol. 8, Issue 1, pp. 5477, 2018 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut) (Probematerial (Species): Human).

Guo, Grimmig, Gonzalez, Giobbie-Hurder, Berg, Carr, Wilson, Banerjee, Ma, Gold, Nandi, Huang, Waaga-Gasser, Lian, Murphy, Frank, Gasser, Frank: "ATP-binding cassette member B5 (ABCB5) promotes tumor cell invasiveness in human colorectal cancer." in: The Journal of biological chemistry, Vol. 293, Issue 28, pp. 11166-11178, 2018 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

Sato, Suda, Shimizu, Sakai, Mizuuchi, Tomizawa, Takemoto, Nishio, Mitsudomi: "Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression." in: PLoS ONE, Vol. 11, Issue 4, pp. e0154186, 2017 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Probematerial (Species): Human).

Lock, Ingraham, Maertens, Miller, Weledji, Legius, Konicek, Yan, Graff, Cichowski: "Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers." in: The Journal of clinical investigation, Vol. 126, Issue 6, pp. 2181-90, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

Richard, Dalle, Monet, Ligier, Boespflug, Pommier, de la Fouchardière, Perier-Muzet, Depaepe, Barnault, Tondeur, Ansieau, Thomas, Bertolotto, Ballotti, Mourah, Battistella, Lebbé, Thomas, Puisieux et al.: "ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors. ..." in: EMBO molecular medicine, Vol. 8, Issue 10, pp. 1143-1161, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

von Mässenhausen, Brägelmann, Billig, Thewes, Queisser, Vogel, Kristiansen, Schröck, Bootz, Brossart, Kirfel, Perner: "Implication of the Receptor Tyrosine Kinase AXL in Head and Neck Cancer Progression." in: International journal of molecular sciences, Vol. 18, Issue 1, 2017 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (IHC), Immunohistochemistry (IHC) (Probematerial (Species): Human).

Aagaard, Lahon, Suter, Arya, Seferovic, Vogt, Hu, Stossi, Mancini, Harris, Kahr, Eppes, Rac, Belfort, Park, Lacorazza, Rico-Hesse: "Primary Human Placental Trophoblasts are Permissive for Zika Virus (ZIKV) Replication." in: Scientific reports, Vol. 7, pp. 41389, 2017 (PubMed). Von den Autoren verwendete Methode: Immunocytochemistry (ICC), Immunocytochemistry (ICC) (Probematerial (Species): Human).

Richard, Shim, Kwon, Zhang, Otsuka, Schmitt, Berri, Diamond, Choe: "AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 8, pp. 2024-2029, 2017 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut), Neutralization (Neut) (Probematerial (Species): Human).

Hastings, Yockey, Jagger, Hwang, Uraki, Gaitsch, Parnell, Cao, Mysorekar, Rothlin, Fikrig, Diamond, Iwasaki: "TAM Receptors Are Not Required for Zika Virus Infection in Mice." in: Cell reports, Vol. 19, Issue 3, pp. 558-568, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

Kanzaki, Naito, Kise, Takara, Eino, Minami, Shintani, Funaki, Kawamura, Kimura, Okumura, Takakura: "Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy." in: Scientific reports, Vol. 7, Issue 1, pp. 10613, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

Cross, Potter, Aldo, Kwon, Pitruzzello, Tong, Guller, Rothlin, Mor, Abrahams: "Viral Infection Sensitizes Human Fetal Membranes to Bacterial Lipopolysaccharide by MERTK Inhibition and Inflammasome Activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 199, Issue 8, pp. 2885-2895, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

Leighl, Tsao, Liu, Tu, Ho, Shepherd, Murray, Goffin, Nicholas, Sakashita, Chen, Kim, Powers, Seymour, Goss, Bradbury: "A phase I study of foretinib plus erlotinib in patients with previously treated advanced non-small cell lung cancer: Canadian cancer trials group IND.196." in: Oncotarget, Vol. 8, Issue 41, pp. 69651-69662, 2017 (PubMed). Von den Autoren verwendete Methode: Immunohistochemistry (IHC), Immunohistochemistry (IHC) (Probematerial (Species): Human).

Kariolis, Miao, Diep, Nash, Olcina, Jiang, Jones, Kapur, Mathews, Koong, Rankin, Cochran, Giaccia: "Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies." in: The Journal of clinical investigation, Vol. 127, Issue 1, pp. 183-198, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Mouse (Murine)).

de Polo, Luo, Gerarduzzi, Chen, Little, Yuan: "AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex." in: Journal of molecular cell biology, Vol. 9, Issue 2, pp. 154-165, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB) (Probematerial (Species): Human).

Dantas-Barbosa, Lesluyes, Loarer, Chibon, Treilleux, Coindre, Meeus, Brahmi, Bally, Ray-Coquard, Sunyach, Cesne, Mir, Bonvalot, Toulmonde, Italiano, Saintigny, Jean-Denis, Ducimetiere, Ranchere et al.: "Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma. ..." in: British journal of cancer, Vol. 117, Issue 12, pp. 1787-1797, 2017 (PubMed). Von den Autoren verwendete Methode: Flow Cytometry (FACS) (Probematerial (Species): Human).

Fritz, Gustafsson, Ljungberg, Ceder, Axelson, Dahlbäck: "The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels." in: PLoS ONE, Vol. 10, Issue 8, pp. e0135991, 2016 (PubMed). Von den Autoren verwendete Methode: Flow Cytometry (FACS), Flow Cytometry (FACS) (Probematerial (Species): Human).

Happonen, Tran, Mörgelin, Prince, Calzavarini, Angelillo-Scherrer, Dahlbäck: "The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles." in: The Journal of biological chemistry, Vol. 291, Issue 20, pp. 10586-601, 2016 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

Retallack, Di Lullo, Arias, Knopp, Laurie, Sandoval-Espinosa, Mancia Leon, Krencik, Ullian, Spatazza, Pollen, Mandel-Brehm, Nowakowski, Kriegstein, DeRisi: "Zika virus cell tropism in the developing human brain and inhibition by azithromycin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 50, pp. 14408-14413, 2016 (PubMed). Von den Autoren verwendete Methode: Neutralization (Neut), Neutralization (Neut) (Probematerial (Species): Human).

Rho, Choi, Kim, Kim, Choi, Yoon, Park, Park, Bae, Choi, Lee: "MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation." in: Cancer research, Vol. 74, Issue 1, pp. 253-62, 2014 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Western Blotting (WB) (Probematerial (Species): Human).

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