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PPP1R9B Antikörper (AA 358-460) (Alexa Fluor 680)

PPP1R9B Reaktivität: Ratte, Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 680
Produktnummer ABIN5010939
  • Target Alle PPP1R9B Antikörper anzeigen
    PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))
    Bindungsspezifität
    • 14
    • 9
    • 9
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 358-460
    Reaktivität
    • 31
    • 25
    • 25
    Ratte, Maus
    Wirt
    • 44
    • 1
    • 1
    Kaninchen
    Klonalität
    • 46
    Polyklonal
    Konjugat
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PPP1R9B Antikörper ist konjugiert mit Alexa Fluor 680
    Applikation
    • 38
    • 21
    • 12
    • 12
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus, Ratte
    Homologie
    Human,Dog,Sheep,Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Spinophilin/Neurabin 2
    Isotyp
    IgG
    Top Product
    Discover our top product PPP1R9B Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))
    Andere Bezeichnung
    Spinophilin/Neurabin 2 (PPP1R9B Produkte)
    Synonyme
    Neb2 antikoerper, PPP1R6 antikoerper, PPP1R9 antikoerper, SPINO antikoerper, Spn antikoerper, SPL antikoerper, protein phosphatase 1, regulatory subunit 9B antikoerper, protein phosphatase 1 regulatory subunit 9B antikoerper, Ppp1r9b antikoerper, PPP1R9B antikoerper
    Hintergrund

    Synonyms: Spn, SPINO, PPP1R6, PPP1R9, Neurabin-2, Neurabin-II, Protein phosphatase 1 regulatory subunit 9B, Spinophilin, PPP1R9B

    Background: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.

    Gen-ID
    84687
    UniProt
    Q96SB3
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling
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