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CRADD Antikörper (C-Term)

CRADD Reaktivität: Human WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500563
  • Target Alle CRADD Antikörper anzeigen
    CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
    Bindungsspezifität
    • 16
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 47
    • 5
    • 2
    Human
    Wirt
    • 42
    • 5
    • 1
    • 1
    Kaninchen
    Klonalität
    • 41
    • 8
    Polyklonal
    Konjugat
    • 29
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CRADD Antikörper ist unkonjugiert
    Applikation
    • 38
    • 21
    • 9
    • 8
    • 8
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects RAIDD at C-term.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    RAIDD antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human RAIDD.
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western blot: 1: 500 - 1: 1000, a 22 kDa band should be detected. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
    Andere Bezeichnung
    RAIDD (CRADD Produkte)
    Synonyme
    cradd antikoerper, MGC89035 antikoerper, zgc:101717 antikoerper, CRADD antikoerper, DKFZp468A2219 antikoerper, LOC100226369 antikoerper, raidd antikoerper, MGC78788 antikoerper, MRT34 antikoerper, RAIDD antikoerper, CASP2 and RIPK1 domain containing adaptor with death domain antikoerper, CASP2 and RIPK1 domain containing adaptor with death, gene 1 antikoerper, CASP2 and RIPK1 domain containing adaptor with death, gene 2 S homeolog antikoerper, CRADD antikoerper, cradd.1 antikoerper, cradd antikoerper, cradd.2.S antikoerper, Cradd antikoerper
    Hintergrund
    Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1,RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.Synonyms: CRADD, Caspase and RIP adapter with death domain, Death domain-containing protein CRADD, RIP-associated protein with a death domain
    Gen-ID
    8738
    UniProt
    P78560
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity
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