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Coagulation Factor VIII-Associated 1 (F8A1) (AA 2-80) Antikörper (Alexa Fluor 680)

F8A1 Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 680
Produktnummer ABIN5004230
  • Target Alle Coagulation Factor VIII-Associated 1 (F8A1) Antikörper anzeigen
    Coagulation Factor VIII-Associated 1 (F8A1)
    Bindungsspezifität
    • 14
    • 1
    • 1
    • 1
    AA 2-80
    Reaktivität
    • 18
    • 2
    • 1
    Human
    Wirt
    • 19
    Kaninchen
    Klonalität
    • 19
    Polyklonal
    Konjugat
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Alexa Fluor 680
    Applikation
    • 19
    • 12
    • 12
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Cow
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human HAP40
    Isotyp
    IgG
    Top Product
    Discover our top product F8A1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Coagulation Factor VIII-Associated 1 (F8A1)
    Andere Bezeichnung
    HAP40/F8a (F8A1 Produkte)
    Synonyme
    DXS522E antikoerper, F8A antikoerper, HAP40 antikoerper, F8a antikoerper, Hap40 antikoerper, RGD1566014 antikoerper, f8a antikoerper, f8a1 antikoerper, hap40 antikoerper, dxs522e antikoerper, MGC147036 antikoerper, coagulation factor VIII associated 1 antikoerper, coagulation factor VIII-associated 1 antikoerper, coagulation factor VIII antikoerper, F8A1 antikoerper, F8a1 antikoerper, f8a1 antikoerper
    Hintergrund

    Synonyms: Coagulation factor 8 associated intronic transcript 1, Coagulation factor VIII associated intronic transcript 1, CpG island protein, DXS522E, F8a, F8A1, F8A2, F8A3, Factor 8 associated protein, Factor 8 intron 22 protein, Factor VIII associated protein, Factor VIII intron 22 protein, huntingtin associated protein 40, F8I2_HUMAN.

    Background: The Huntingtin protein contains a polyglutamine region, which leads to Huntingtin?s disease (HD) when the number of glutamine repeats exceeds thirty-five. The mutated Huntingtin protein acts within the nucleus to induce neurodegeneration by a cell-specific apoptotic mechanism. The loss of activity of the Huntingtin protein may be contributed to abnormal interactions between the mutant protein and other associated cellular proteins. Huntingtin interacts with a variety of proteins including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), HAP40, Rab5 and HIP1. HAP40 mediates the recruitment of Huntingtin by Rab5 onto early endosomes. Specifically, this complex regulates endosome motility, which may be a key event of the pathogenetic process leading to neurodegeneration in HD.

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