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Transportin 1 Antikörper (Center)

TNPO1 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN500232
  • Target Alle Transportin 1 (TNPO1) Antikörper anzeigen
    Transportin 1 (TNPO1)
    Bindungsspezifität
    • 8
    • 8
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    Center
    Reaktivität
    • 41
    • 22
    • 19
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 38
    • 4
    • 1
    Kaninchen
    Klonalität
    • 39
    • 4
    Polyklonal
    Konjugat
    • 18
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Transportin 1 Antikörper ist unkonjugiert
    Applikation
    • 41
    • 19
    • 17
    • 14
    • 13
    • 7
    • 5
    • 4
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects MIP1 at center.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse, rat
    Aufreinigung
    Peptide affinity chromatography
    Immunogen
    MAPKAP1 antibody was raised against a 18 amino acid peptide from near the center of human MAPKAP1.
    Isotyp
    IgG
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    Discover our top product TNPO1 Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    Transportin 1 (TNPO1)
    Andere Bezeichnung
    MIP1 (TNPO1 Produkte)
    Synonyme
    IPO2 antikoerper, KPNB2 antikoerper, MIP antikoerper, MIP1 antikoerper, TRN antikoerper, TNPO1 antikoerper, AU021749 antikoerper, D13Ertd688e antikoerper, Kpnb2 antikoerper, ATTRN1 antikoerper, F12A24.13 antikoerper, F12A24_13 antikoerper, TRANSPORTIN 1 antikoerper, transportin 1 antikoerper, DKFZp469O204 antikoerper, transportin 1 antikoerper, transportin-1 antikoerper, transportin 1 S homeolog antikoerper, TNPO1 antikoerper, LOC738932 antikoerper, tnpo1 antikoerper, Tnpo1 antikoerper, tnpo1.S antikoerper, TRN1 antikoerper
    Hintergrund
    MAPKAP1 was initially identified as the human homolog of S. pombe SIN1. Recent evidence has shown that it identical to Mip1, a protein that interacts with MEKK2, a member of the mitogen-activated protein kinase (MAPK) intracellular signaling network. MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with the inactive and non-phosphorylated MEKK2, thereby blocking the JNK1/2, ERK1/2, p38 and ERK5 MAPKs. MAPKAP1 has also been shown to play a role in the TOR signaling process, a pathway that is involved in controlling cell growth and proliferation in response to environmental cues such as nutrients, growth factors and hormones. Experiments showed that MAPKAP1 helped to maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, which allowed specific phosphorylation of Akt, a kinase that is believed to couple the growth factor-PI3K signaling pathway to the nutrient-regulated TOR signaling pathway. Multiple alternatively spliced isoforms of MAPKAP1 have been identified.Synonyms: MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, SAPK-interacting protein 1, SIN1, Stress-activated map kinase-interacting protein 1, TORC2 subunit MAPKAP1, Target of rapamycin complex 2 subunit MAPKAP1, mSIN1
    Gen-ID
    79109
    NCBI Accession
    NP_001006618
    UniProt
    Q9BPZ7
    Pathways
    PI3K-Akt Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Cellular Glucan Metabolic Process, Protein targeting to Nucleus, CXCR4-mediated Signaling Events
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