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TEFM Antikörper (AA 60-110) (Alexa Fluor 750)

TEFM Reaktivität: Human, Maus, Ratte WB, IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 750
Produktnummer ABIN4997940
  • Target Alle TEFM Antikörper anzeigen
    TEFM (Transcription Elongation Factor, Mitochondrial (TEFM))
    Bindungsspezifität
    • 14
    • 4
    • 2
    • 1
    • 1
    AA 60-110
    Reaktivität
    • 23
    • 15
    • 15
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 23
    Kaninchen
    Klonalität
    • 23
    Polyklonal
    Konjugat
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TEFM Antikörper ist konjugiert mit Alexa Fluor 750
    Applikation
    • 18
    • 12
    • 3
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human C17orf42
    Isotyp
    IgG
    Top Product
    Discover our top product TEFM Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    TEFM (Transcription Elongation Factor, Mitochondrial (TEFM))
    Andere Bezeichnung
    C17orf42 (TEFM Produkte)
    Synonyme
    C17orf42 antikoerper, TEFM antikoerper, zgc:153083 antikoerper, RGD1306595 antikoerper, transcription elongation factor, mitochondrial antikoerper, TEFM antikoerper, tefm antikoerper, Tefm antikoerper
    Hintergrund

    Synonyms: Chromosome 17 open reading frame 42, FLJ22729, Hypothetical protein LOC79736, MGC24674, UPF0629 protein C17orf42, TEFM_HUMAN, TEFM, transcription elongation factor, mitochondrial,

    Background: C17orf42 is a 360 amino acid protein that exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

    Gen-ID
    79736
    UniProt
    Q96QE5
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