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DFFB Antikörper (N-Term)

DFFB Reaktivität: Human WB, IF, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN499738
  • Target Alle DFFB Antikörper anzeigen
    DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
    Bindungsspezifität
    • 15
    • 15
    • 14
    • 9
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 55
    • 45
    • 24
    Human
    Wirt
    • 72
    • 4
    Kaninchen
    Klonalität
    • 73
    • 3
    Polyklonal
    Konjugat
    • 34
    • 5
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser DFFB Antikörper ist unkonjugiert
    Applikation
    • 57
    • 29
    • 26
    • 26
    • 18
    • 14
    • 11
    • 10
    • 6
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Spezifität
    DFF40 antibody was raised against a peptide corresponding to amino acids 3 to 18 of human DFF40.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    Human DFF40 (N-Terminus) Peptide
    Isotyp
    IgG
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  • Applikationshinweise
    ELISA. Western Blot: 1/500 to 1/2000. A 40 kDa band can be detected. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C.
  • Target
    DFFB (DNA Fragmentation Factor, 40kDa, beta Polypeptide (Caspase-Activated DNase) (DFFB))
    Andere Bezeichnung
    DFFB / CAD (DFFB Produkte)
    Synonyme
    CAD antikoerper, CPAN antikoerper, DFF-40 antikoerper, DFF2 antikoerper, DFF40 antikoerper, LOC100223514 antikoerper, 40kDa antikoerper, 5730477D02Rik antikoerper, Didff antikoerper, Cad antikoerper, carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase antikoerper, DNA fragmentation factor subunit beta antikoerper, DNA fragmentation factor, beta polypeptide (caspase-activated DNase) antikoerper, DNA fragmentation factor, beta subunit antikoerper, CAD antikoerper, DFFB antikoerper, dffb antikoerper, LOC100223514 antikoerper, Dffb antikoerper
    Hintergrund
    Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD for caspase activated deoxyribonuclease (1,2). The human homologue of mouse CAD was more recently identified by three groups independently and termed CPAN, DFF40, and human CAD, respectively, (3-5). DFF45/ICAD is the inhibitory protein of DFF40/CAD (1,2,6) and forms complex with DFF40/CAD. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of DFF40/CAD, which causes DNA degradation, is the hallmark of apoptotic cell death.Synonyms: CPAN, Caspase-activated DNase, Caspase-activated deoxyribonuclease, Caspase-activated nuclease, DFF-40, DFF2, DFF40, DNA fragmentation factor 40 kDa subunit, DNA fragmentation factor subunit beta
    Gen-ID
    1677
    NCBI Accession
    NP_004393
    UniProt
    O76075
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose
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