SCN2A Antikörper

Produktnummer ABIN498571

Produktdetails anti-SCN2A Antikörper

Target: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SCN2A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Na+ CP type II-alpha protein. (region surrounding Lys1032)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SCN2A

Target: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Andere Bezeichnung: SCN2A (SCN2A Produkte)

Synonyme: SCN2A2 antikoerper, 6430408L10 antikoerper, A230052E19Rik antikoerper, Nav1.2 antikoerper, Scn2a antikoerper, NachII antikoerper, RII/RIIA antikoerper, RNSCPIIR antikoerper, SCN antikoerper, SCN2A antikoerper, Scn2a2 antikoerper, ScpII antikoerper, BFIC3 antikoerper, BFIS3 antikoerper, BFNIS antikoerper, EIEE11 antikoerper, HBA antikoerper, HBSCI antikoerper, HBSCII antikoerper, NAC2 antikoerper, Na(v)1.2 antikoerper, SCN2A1 antikoerper, sodium voltage-gated channel alpha subunit 2 antikoerper, sodium channel protein type 2 subunit alpha antikoerper, sodium channel, voltage-gated, type II, alpha antikoerper, sodium channel, voltage-gated, type II, alpha subunit antikoerper, SCN2A antikoerper, LOC100217927 antikoerper, LOC100389294 antikoerper, LOC100484218 antikoerper, Scn2a antikoerper, LOC478773 antikoerper

Hintergrund: Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, which rapidly depolarize the cell. The three glycoproteins that comprise the voltagegated sodium channel proteins include a pore-forming alpha subunit, a noncovalently associated beta1 subunit and a disulfidelinked beta2 subunit. The two beta subunits regulate the level of channel expression, modulate gating and function as cell adhesion molecules for cellular aggregation and cytoskeleton interaction. The alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type IIalpha subunits are more abundant along axons. The beta1 subunit of sodium channel type I is expressed in brain, skeletal and cardiac muscle. In the brain, beta1 and beta2 are highly expressed in Purkinje cells, and beta1 is also expressed in the pyramidal cells of the deep cerebellar nuclei. Impaired voltage-gated sodium channels lead to a number of diseases including myotonia.Synonyms: HBSC II, NAC2, SCN2A1, SCN2A2, Sodium channel protein brain II subunit alpha, Sodium channel protein type 2 subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.2

Gen-ID: 6326

NCBI Accession: NP_001035232

UniProt: Q99250