IRX1 Antikörper

Produktnummer ABIN498327

Produktdetails anti-IRX1 Antikörper

Target: IRX1 (Iroquois Homeobox Protein 1 (IRX1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IRX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of IRX1 protein. (region surrounding Asp231)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography using epitope-specific immunogen

Reinheit: > 95 % (by SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu IRX1

Target: IRX1 (Iroquois Homeobox Protein 1 (IRX1))

Andere Bezeichnung: IRX1 / IRXA1 (IRX1 Produkte)

Synonyme: IRX-5 antikoerper, IRXA1 antikoerper, IRX1 antikoerper, Xiro antikoerper, Xiro1 antikoerper, iro1 antikoerper, irx-5 antikoerper, irx1 antikoerper, zgc:109702 antikoerper, zgc:136490 antikoerper, ziro1 antikoerper, ziro1a antikoerper, Xiro-1 antikoerper, iro1-A antikoerper, iro1-B antikoerper, irx1-a antikoerper, irx1-b antikoerper, iroquois homeobox 1 antikoerper, Iroquois related homeobox 1 (Drosophila) antikoerper, iroquois homeobox 1a antikoerper, iroquois homeobox 1 L homeolog antikoerper, Putative iroquois-class homeodomain protein irx-1 antikoerper, iroquois homeobox 1 S homeolog antikoerper, IRX1 antikoerper, Irx1 antikoerper, irx1 antikoerper, irx1a antikoerper, irx1.L antikoerper, irx-1 antikoerper, irx1.S antikoerper

Hintergrund: The Iroquois homeobox gene family of transcription factors regulate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system. The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice. The IRXA group includes Irx1, Irx2 and Irx4, the IRXB group is comprises Irx3, Irx5 and Irx6. Irx1 and Irx2 are both widely expressed during development in the lung epithelium and also in the ventricular septum. Irx1 and Irx2 also play a role in digit formation (E11.5-E14.5). The Irx gene family members are each expressed in a distinct pattern during mouse heart development. Specifically, Irx1 and Irx2 are expressed in the ventricular septum and Irx3 is expressed in the ventricular trabeculated myocardium. In addition, Irx4 is expressed in the linear heart tube and the AV canal, Irx5 is expressed in the endocardium lining the ventricular and atrial myocardium. Furthermore, the IRX4 gene may modulate cardiac development and function. Although the heart of Irx4- mice appears to develop normally, adult Irx4- mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility.Synonyms: Homeodomain protein IRXA1, IRX-1, Iroquois homeobox protein 1, Iroquois-class homeodomain protein IRX-1

Molekulargewicht: approx. 47 kDa

Gen-ID: 79192

NCBI Accession: NP_077313

UniProt: P78414

Pathways: Tube Formation