ADRA2A Antikörper

Produktnummer ABIN498305

Produktdetails anti-ADRA2A Antikörper

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ADRA2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of AR alpha-2A protein. (region surrounding Arg361)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200. Immunofluorescence: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ADRA2A

Target: ADRA2A (Alpha-2A Adrenergic Receptor (ADRA2A))

Andere Bezeichnung: alpha-2A Adrenergic Receptor (ADRA2A Produkte)

Synonyme: ADRA2A antikoerper, AW122659 antikoerper, Adra-2 antikoerper, Adra-2a antikoerper, alpha(2A)AR antikoerper, alpha2-C10 antikoerper, alpha2A antikoerper, alpha2A-AR antikoerper, ADRA2 antikoerper, ADRA2R antikoerper, ADRAR antikoerper, ALPHA2AAR antikoerper, ZNF32 antikoerper, CA2-47 antikoerper, RATRG20 antikoerper, RG20 antikoerper, PORA2AR antikoerper, adrenoceptor alpha 2A antikoerper, alpha-2A adrenergic receptor-like antikoerper, adrenergic receptor, alpha 2a antikoerper, adra2a antikoerper, ADRA2A antikoerper, LOC100414445 antikoerper, Adra2a antikoerper

Hintergrund: This study investigates the involvement of alpha2-adrenergic receptors (AR) in mouse brain induced by a low dose of methamphetamine (METH, 2 mg/kg). Immunohistochemical studies show that alpha2A-AR increased in the dentate gyrus area of the hippocampus 24 h after five repeated administrations of METH. The hippocampal alpha2A-AR proteins rose 3.2-fold when compared to the saline-administered mice. The other adrenergic receptor, apha1D-AR, were not changed by the treatment. Moreover, alphao-subunits of GTP-binding proteins (Galphao), one of the downstream molecules of alpha2A-AR, was also increased by the treatment. These suggest that the repeated administration of low-doses of METH causes quantitative changes of the signaling of alpha2A-AR in the mouse hippocampus.Synonyms: ADRA2A, ADRA2R, ADRAR, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor

Molekulargewicht: approx. 48 kDa

Gen-ID: 150

NCBI Accession: NP_000672

UniProt: P08913

Pathways: EGFR Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Negative Regulation of Transporter Activity