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DUSP1 Antikörper

DUSP1 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN498155
  • Target Alle DUSP1 Antikörper anzeigen
    DUSP1 (Dual Specificity Phosphatase 1 (DUSP1))
    Reaktivität
    • 85
    • 35
    • 34
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 81
    • 3
    • 1
    Kaninchen
    Klonalität
    • 74
    • 11
    Polyklonal
    Konjugat
    • 29
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser DUSP1 Antikörper ist unkonjugiert
    Applikation
    • 64
    • 37
    • 27
    • 26
    • 14
    • 11
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody detects endogenous levels of MKP1 protein.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Affinity chromatography using epitope-specific immunogen
    Reinheit
    > 95 % (by SDS-PAGE)
    Top Product
    Discover our top product DUSP1 Primärantikörper
  • Applikationshinweise
    Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Target
    DUSP1 (Dual Specificity Phosphatase 1 (DUSP1))
    Andere Bezeichnung
    DUSP1 / MKP1 (DUSP1 Produkte)
    Synonyme
    CL100 antikoerper, HVH1 antikoerper, MKP-1 antikoerper, MKP1 antikoerper, PTPN10 antikoerper, 3CH134 antikoerper, Mkp1 antikoerper, Ptpn16 antikoerper, DUSP1 antikoerper, U19515 antikoerper, erp antikoerper, mkp-1 antikoerper, cb269 antikoerper, sb:cb269 antikoerper, zgc:55920 antikoerper, id:ibd2586 antikoerper, wu:fd19g02 antikoerper, wu:fe50g09 antikoerper, XCL100 antikoerper, dual specificity phosphatase 1 antikoerper, dual specificity phosphatase 1 S homeolog antikoerper, DUSP1 antikoerper, Dusp1 antikoerper, dusp1 antikoerper, dusp1.S antikoerper
    Hintergrund
    The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.Synonyms: CL100, Dual specificity protein phosphatase 1, Dual specificity protein phosphatase hVH1, MAP kinase phosphatase 1, MKP-1, PTPN10, Protein-tyrosine phosphatase CL100, VH1
    Molekulargewicht
    approx. 39 kDa
    Gen-ID
    1843
    NCBI Accession
    NP_004408
    UniProt
    P28562
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