GABRG2 Antikörper (Internal Region)

Produktnummer ABIN498030

Produktdetails anti-GABRG2 Antikörper

Target: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Bindungsspezifität: AA 400-410, Internal Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh)

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser GABRG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-NNATHLQERD E

Spezifität: This antibody is expected to recognize all reported isoforms: NP_944494.1, NP_000807.2, NP_944493.2.

Kreuzreaktivität (Details): Species reactivity (expected):Human, Bovine.
Species reactivity (tested):Mouse, Rat.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_944494.1, NP_000807.2, NP_944493.2. Genename: GABRG2

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit Dilution: 1/16000. Western blot: 1-3 μg/mL. Approx 50 kDa band observed in Mouse and Rat Brain lysates(calculated MW of 55.0 kDa according to Mouse NP_032099.1 and 54.0 kDa according to RatNP_899156.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GABRG2

Target: GABRG2 (gamma-aminobutyric Acid (GABA) A Receptor, gamma 2 (GABRG2))

Andere Bezeichnung: GABRG2 (GABRG2 Produkte)

Synonyme: cae2 antikoerper, eca2 antikoerper, gabrg1 antikoerper, gefsp3 antikoerper, si:ch211-145n14.1 antikoerper, CAE2 antikoerper, ECA2 antikoerper, GEFSP3 antikoerper, GABAA-R antikoerper, Gabrg-2 antikoerper, gamma2 antikoerper, gamma-aminobutyric acid type A receptor gamma2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, gamma 2 antikoerper, gamma-aminobutyric acid type A receptor gamma 2 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 antikoerper, GABRG2 antikoerper, gabrg2 antikoerper, Gabrg2 antikoerper

Hintergrund: GABA A receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA A. Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA A Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics. The binding of GABA to GABA A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system "overload" can resulting in blackouts, rapid body contractions, seizures and epilepsy.Synonyms: GABA A Receptor subunit gamma-2, GABRG-2, Gamma-aminobutyric acid receptor subunit gamma-2

Gen-ID: 2566

NCBI Accession: NP_000807

UniProt: P18507