Complement Factor I Antikörper

Produktnummer ABIN4955823

Produktdetails anti-Complement Factor I Antikörper

Target: Complement Factor I (CFI)

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Complement Factor I Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Aufreinigung: Antigen affinity

Immunogen: Amino acids K19-D220 were used as the immunogen for the Factor I antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: 0.1-0.5 μg/mL,FACS: 1-3 μg/10^6 cells

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Factor I antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu Complement Factor I

Target: Complement Factor I (CFI)

Andere Bezeichnung: Complement Factor I / CFI (CFI Produkte)

Synonyme: cfi antikoerper, MGC53615 antikoerper, Cfi antikoerper, factor I antikoerper, IF antikoerper, gb:ai721528 antikoerper, ahus3 antikoerper, c3b-ina antikoerper, c3bc4bi antikoerper, c3bina antikoerper, kaf antikoerper, CFI antikoerper, AHUS3 antikoerper, C3BINA antikoerper, C3b-INA antikoerper, FI antikoerper, KAF antikoerper, complement factor I S homeolog antikoerper, complement factor I L homeolog antikoerper, complement factor I antikoerper, complement component factor i antikoerper, cfi.S antikoerper, cfi.L antikoerper, CFI antikoerper, cfi antikoerper, Cfi antikoerper

Hintergrund: Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene.

UniProt: P05156

Pathways: Komplementsystem