HLA-A Antikörper (AA 70-99)

Produktnummer ABIN3031678

Produktdetails anti-HLA-A Antikörper

Target: HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))

Bindungsspezifität: AA 70-99

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HLA-A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): Expected species reactivity: Human

Aufreinigung: Purified

Immunogen: A portion of amino acids 70-99 from the human protein was used as the immunogen for this HLA-A antibody.

Klon: 7G7F9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Titration of the HLA-A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS pH 7.4 with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot the HLA-A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Details zu HLA-A

Target: HLA-A (Major Histocompatibility Complex, Class I, A (HLA-A))

Andere Bezeichnung: HLA-A (HLA-A Produkte)

Synonyme: HLAA antikoerper, major histocompatibility complex, class I, A antikoerper, HLA-A antikoerper

Hintergrund: HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.

UniProt: P04439

Pathways: T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints