Titration of the ABCG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Immunofluorescence: 1:10-1:50,Flow Cytometry: 1:10-1:50,IHC (Paraffin): 1:50-1:100
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
In 1X PBS, pH 7.4, with 0.09 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
Aliquot the ABCG2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Target
ABCG2
(ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 (ABCG2))
bcrp antikoerper, ABCG2 antikoerper, ABC15 antikoerper, ABCP antikoerper, BCRP antikoerper, BCRP1 antikoerper, BMDP antikoerper, CD338 antikoerper, CDw338 antikoerper, EST157481 antikoerper, GOUT1 antikoerper, MRX antikoerper, MXR antikoerper, MXR1 antikoerper, UAQTL1 antikoerper, AI428558 antikoerper, Bcrp1 antikoerper, ABCG3 antikoerper, ATP binding cassette subfamily G member 2 antikoerper, ATP binding cassette subfamily G member 2 (Junior blood group) antikoerper, ATP binding cassette subfamily G member 2 (Junior blood group) L homeolog antikoerper, ATP-binding cassette, sub-family G (WHITE), member 2 antikoerper, ATP-binding cassette sub-family G member 2 antikoerper, ABCG2 antikoerper, abcg2 antikoerper, abcg2.L antikoerper, Abcg2 antikoerper, LOC100008640 antikoerper
Hintergrund
ABCG2 is a membrane-associated protein included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.