Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

XBP1 Antikörper

XBP1 Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN4953115
  • Target Alle XBP1 Antikörper anzeigen
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Reaktivität
    • 69
    • 42
    • 10
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    Human, Maus, Ratte
    Wirt
    • 68
    • 11
    • 1
    Kaninchen
    Klonalität
    • 68
    • 12
    Polyklonal
    Konjugat
    • 43
    • 7
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser XBP1 Antikörper ist unkonjugiert
    Applikation
    • 74
    • 44
    • 28
    • 19
    • 14
    • 13
    • 12
    • 9
    • 6
    • 4
    • 3
    • 3
    • 3
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Antigen affinity
    Immunogen
    Amino acids RKRQRLTHLSPEEKALRRKLKNRVAAQ of human XBP1 were used as the immunogen for the XBP1 antibody.
    Isotyp
    IgG
    Top Product
    Discover our top product XBP1 Primärantikörper
  • Applikationshinweise
    Optimal dilution of the XBP1 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Lagerung
    -20 °C
    Informationen zur Lagerung
    After reconstitution, the XBP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    XBP1 (X-Box Binding Protein 1 (XBP1))
    Andere Bezeichnung
    XBP1 (XBP1 Produkte)
    Synonyme
    treb5 antikoerper, xXBP1 antikoerper, xbp2 antikoerper, XBP1P1 antikoerper, XBPP1 antikoerper, xbp1 antikoerper, TREB5 antikoerper, XBP-1 antikoerper, XBP2 antikoerper, D11Ertd39e antikoerper, TREB-5 antikoerper, HTF antikoerper, cb918 antikoerper, id:ibd1195 antikoerper, trebf antikoerper, wu:fb02h05 antikoerper, wu:fb63f10 antikoerper, xbp1a antikoerper, xbp1b antikoerper, X-box binding protein 1 antikoerper, X-box binding protein 1 L homeolog antikoerper, xbp1 antikoerper, XBP1 antikoerper, Xbp1 antikoerper, xbp1.L antikoerper
    Hintergrund
    XBP1, also known as X-box binding protein 1, is a protein which in humans is encoded by the XBP1 gene. It encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
    UniProt
    P17861
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
Sie sind hier:
Kundenservice