DIABLO Antikörper (AA 56-239)

Produktnummer ABIN4952604

Produktdetails anti-DIABLO Antikörper

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Bindungsspezifität: AA 56-239

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DIABLO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Amino acids 56-239 of human Smac/Diablo were used as the immunogen for the Smac antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Smac antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the Smac antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu DIABLO

Target: DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))

Andere Bezeichnung: Smac / Diablo (DIABLO Produkte)

Synonyme: smac antikoerper, smac3 antikoerper, diablo-s antikoerper, 0610041G12Rik antikoerper, 1700006L01Rik antikoerper, AU040403 antikoerper, Smac antikoerper, DFNA64 antikoerper, SMAC antikoerper, DBO antikoerper, XSmac antikoerper, diablo, IAP-binding mitochondrial protein antikoerper, diablo IAP-binding mitochondrial protein antikoerper, diablo, IAP-binding mitochondrial protein L homeolog antikoerper, diablo antikoerper, Diablo antikoerper, DIABLO antikoerper, diablo.L antikoerper

Hintergrund: Diablo homolog (DIABLO), also referred to as second mitochondria-derived activator of caspases or SMAC, is a mitochondrial protein that in humans is encoded by the DIABLO (direct IAP binding protein with low pI) gene on chromosome 12. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: Q9NR28

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity