MAP2K7 Antikörper

Produktnummer ABIN4951736

Produktdetails anti-MAP2K7 Antikörper

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity

Immunogen: Amino acids AASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPR of human MAP2K7 were used as the immunogen for the MKK7 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the MKK7 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the MKK7 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu MAP2K7

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Andere Bezeichnung: MEK7 / MAP2K7 / MKK7 (MAP2K7 Produkte)

Synonyme: MAP2K7 antikoerper, 2 antikoerper, JNKK antikoerper, Jnkk2 antikoerper, Mapkk7 antikoerper, Mek7 antikoerper, Mkk7 antikoerper, MAPKK7 antikoerper, MKK7 antikoerper, PRKMK7 antikoerper, SAPKK-4 antikoerper, SAPKK4 antikoerper, 5930412N11Rik antikoerper, JNKK 2 antikoerper, MAPKK 7 antikoerper, MEK 7 antikoerper, Prkmk7 antikoerper, sek2 antikoerper, si:ch211-254d18.2 antikoerper, map2k7-A antikoerper, mitogen-activated protein kinase kinase 7 antikoerper, mitogen activated protein kinase kinase 7 antikoerper, mitogen-activated protein kinase kinase 7 L homeolog antikoerper, MAP2K7 antikoerper, Map2k7 antikoerper, map2k7 antikoerper, map2k7.L antikoerper

Hintergrund: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. [UniProt]

UniProt: O14733

Pathways: MAPK Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling